Scaffold Proposal

The submission criteria of a proposed scaffold to be considered in CC4CARB are:


  • Description of the scaffold, preferably a structure.
  • Rationale for why the scaffold represents a compelling hypothesis involving the treatment of Gram-negative or antibiotic resistant Gram-positive infections, plus references.
  • Vision for testing scaffold analogs, including key microbes if known. Ability to test compounds is not required.
  • Library design concepts are welcome, but not necessary. Library design will be a collaborative effort between RTI and the external PI.
  • Curriculum Vitae or NIH Biosketch.
  • Innovation, novelty, and concepts addressing Gram-negative antimicrobial discovery and development will be prioritized if accepted.

Please complete one form for each proposal.